mycobacterium avium subsp. paratuberculosis in an italian cohort of type 1 diabetes pediatric patients
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2012
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Abstract
Mycobacterium avium subsp. paratuberculosis (MAP) is the etiological agent of Johne’s disease in ruminants. Recent studies have linked MAP to type 1 diabetes (T1D) in the Sardinian population. The aim of this study was to investigate the prevalence of MAP infection in a T1D cohort from continental Italy compared with healthy control subjects. 247 T1D subjects and 110 healthy controls were tested for the presence of MAP. MAP DNA was detected using IS900-specific polymerase chain reaction (PCR). The presence of antibodies towards a MAP antigen, heparin binding hemoagglutinin (HBHA), was detected by ELISA. We demonstrated a higher MAP DNA prevalence in plasma samples from T1D patients and a stronger immune response towards MAP HBHA, compared with healthy control subjects. Moreover, in the recent onset patients, we observed an association between anti-MAP antibodies and HLA DQ2 (DQA1 0201/DQB1 0202).
These findings taken together support the hypothesis of MAP as an environmental risk factor for the development of T1D in genetically predisposed subjects, probably involving a mechanism of molecular mimicry between MAP antigens and pancreatic islet β-cells.
| Reference Key |
bitti2012clinicalmycobacterium
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| Authors | ;Maria Luisa Manca Bitti;Speranza Masala;Francesca Capasso;Novella Rapini;Simona Piccinini;Federica Angelini;Andrea Pierantozzi;Roberta Lidano;Silvia Pietrosanti;Daniela Paccagnini;Leonardo A. Sechi |
| Journal | Applied Surface Science |
| Year | 2012 |
| DOI |
10.1155/2012/785262
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