can biparietal diameter-to-femur length ratio be a useful sonographic marker for screening thanatophoric dysplasia since the first trimester? a literature review of case reports and a retrospective study based on 10,293 routine fetal biometry measurements
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2017
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Abstract
Objective: The aim of the study was to determine whether the biparietal diameter/femur length (BPD/FL) ratio can be used to detect thanatophoric dysplasia in the first trimester of pregnancy.
Materials and Methods: Twenty-four reported cases of thanatophoric dysplasia diagnosed based on ultrasonographic results with molecular or radiographic diagnosis were included. All sonographic measurement records were extracted and reviewed, and the BPD/FL ratio was calculated for each gestational week. In addition, 10,293 routine fetal biometry measurements from 1395 cases of patients without skeletal dysplasia were compared.
Results: The BPD/FL ratio in the control group decreased to less than 3 prior to gestational week 13, and to less than 2 prior to week 18. Of the 27 BPD/FL ratios obtained from 24 cases of thanatophoric dysplasia, none was in the control range.
Conclusion: The BPD/FL ratio may be used to detect lethal skeletal dysplasias such as thanatophoric dysplasia since the first trimester.
| Reference Key |
wang2017taiwanesecan
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|---|---|
| Authors | ;Liangcheng Wang;Yasushi Takai;Kazunori Baba;Yukiko Mikami;Masahiro Saito;Isao Horiuchi;Ryo Konno;Kenjiro Takagi;Hiroyuki Seki |
| Journal | spermova |
| Year | 2017 |
| DOI |
10.1016/j.tjog.2017.04.021
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| URL | |
| Keywords | Keywords not found |
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