stem cells toward the future: the space challenge

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ID: 241799
2014
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Abstract
Astronauts experience weightlessness-induced bone loss due to an unbalanced process of bone remodeling that involves bone mesenchymal stem cells (bMSCs), as well as osteoblasts, osteocytes, and osteoclasts. The effects of microgravity on osteo-cells have been extensively studied, but it is only recently that consideration has been given to the role of bone MSCs. These live in adult bone marrow niches, are characterized by their self-renewal and multipotent differentiation capacities, and the published data indicate that they may lead to interesting returns in the biomedical/bioengineering fields. This review describes the published findings concerning bMSCs exposed to simulated/real microgravity, mainly concentrating on how mechanosignaling, mechanotransduction and oxygen influence their proliferation, senescence and differentiation. A comprehensive understanding of bMSC behavior in microgravity and their role in preventing bone loss will be essential for entering the future age of long-lasting, manned space exploration.
Reference Key
bradamante2014lifestem Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Silvia Bradamante;Livia Barenghi;Jeanette A.M. Maier
Journal The Science of the total environment
Year 2014
DOI
10.3390/life4020267
URL
http://www.mdpi.com/2075-1729/4/2/267
Keywords
Bone mesenchymal stem cells osteoblasts microgravity

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