activation of the hypothalamic-pituitary-adrenal stress axis induces cellular oxidative stress

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ID: 241732
2015
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Abstract
Glucocorticoids released from the adrenal gland in response to stress-induced activation of the hypothalamic-pituitary-adrenal (HPA) axis induce activity in the cellular reduction-oxidation (redox) system. The redox system is a ubiquitous chemical mechanism allowing the transfer of electrons between donor/acceptors and target molecules during oxidative phosphorylation while simultaneously maintaining the overall cellular environment in a reduced state. The objective of this review is to present an overview of the current literature discussing the link between HPA axis-derived glucocorticoids and increased oxidative stress, particularly focussing on the redox changes observed in the hippocampus following glucocorticoid exposure.
Reference Key
spiers2015frontiersactivation Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Jereme G. Spiers;Hsiao-Jou Cortina eChen;Conrad eSernia;Nickolas A. Lavidis
Journal Journal of enzyme inhibition and medicinal chemistry
Year 2015
DOI
10.3389/fnins.2014.00456
URL
http://journal.frontiersin.org/Journal/10.3389/fnins.2014.00456/full
Keywords
stress oxidative stress reactive oxygen species corticosterone hypothalamic-pituitary-adrenal axis neuropsychiatry biological psychiatry

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