upregulation of anti-human ribosomal protein s6-p240, topoisomerase ii ά, cyclin d1, bcl-2 and anti-corneal antibodies in acute psoriasis

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ID: 241348
2011
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Abstract
Background. The immunopathogenesis of psoriasis is complex, and involves alterations in the innate immunologic system Case Report: A 57-year-old female was evaluated for the presence of rapidly appearing plaques on the knees and elbows. Methods: Skin biopsies for hematoxylin and eosin examination, as well as for direct immunofluorescence and immunohistochemistry analysis were performed. Results: H&E examination demonstrated classic features of psoriasis. Direct immunofluorescence revealed positive anti-corneal antibodies with several immunoglobulins, as well as positivity to upper and deep small dermal blood vessels. Immunohistochemistry revealed an increased expression of survivin, anti-human-ribosomal protein S6-p240, Topoisomerase II ά, cyclin D1, and Bcl-2 in lesional plaques. Conclusions: The pathobiology of psoriasis seems to involve a series of molecules involved in a complex interaction between the inflammation itself, cell cycle regulation, and ectopic expression of selected molecules.
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r.2011naszaupregulation Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Howard William R.;Abreu Velez Ana Maria;Howard Michael S.
Journal european journal of integrative medicine
Year 2011
DOI
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URL
http://odermatol.like.pl/upload/file/3_%20upregulation%20of%20anti-human(1).pdf
Keywords
psoriasis cyclin d1 topoisomerase ii άdermatology

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