nucleosome conformational flexibility in experiments with single chromatin fibers
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ID: 241212
2010
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Abstract
Studies on the chromatin nucleosome organization play an ever increasing role in our comprehension of mechanisms of the gene activity regulation. This minireview describes the results on the nucleosome conformational flexibility, which were obtained using magnetic tweezers to apply torsion to oligonucleosome fibers reconstituted on single DNA molecules. Such an approach revealed a new structural form of the nucleosome, the reversome, in which DNA is wrapped in a right-handed superhelix around a distorted histone octamer. Molecular mechanisms of the nucleosome structural flexibility and its biological relevance are discussed.
| Reference Key |
v.2010biopolymersnucleosome
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|---|---|
| Authors | ;Sivolob A. V. |
| Journal | medicines |
| Year | 2010 |
| DOI |
10.7124/bc.000169
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| URL | |
| Keywords | Keywords not found |
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