etofibrate but not controlled-release niacin decreases ldl cholesterol and lipoprotein (a) in type iib dyslipidemic subjects

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ID: 240564
2001
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Abstract
Etofibrate is a hybrid drug which combines niacin with clofibrate. After contact with plasma hydrolases, both constituents are gradually released in a controlled-release manner. In this study, we compared the effects of etofibrate and controlled-release niacin on lipid profile and plasma lipoprotein (a) (Lp(a)) levels of patients with triglyceride levels of 200 to 400 mg/dl, total cholesterol above 240 mg/dl and Lp(a) above 40 mg/dl. These patients were randomly assigned to a double-blind 16-week treatment period with etofibrate (500 mg twice daily, N = 14) or niacin (500 mg twice daily, N = 11). In both treatment groups total cholesterol, VLDL cholesterol and triglycerides were equally reduced and high-density lipoprotein cholesterol was increased. Etofibrate, but not niacin, reduced Lp(a) by 26% and low-density lipoprotein (LDL) cholesterol by 23%. The hybrid compound etofibrate produced a more effective reduction in plasma LDL cholesterol and Lp(a) levels than controlled-release niacin in type IIb dyslipidemic subjects.
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sposito2001brazilianetofibrate Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors A.C. Sposito, A.P. Mansur, R.C. Maranhão, C.r.m. Rodrigues-Sobrinho, O.R. Coelho, J.a.f. Ramires
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Journal Free radical biology & medicine
Year 2001
DOI
10.1590/S0100-879X2001000200004
URL
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000200004
Keywords
triglycerides

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