the muc1 ectodomain: a novel and efficient target for gold nanoparticle clustering and vapor nanobubble generation

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ID: 240541
2012
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Ranked #11 of 15 articles by views in cancer epidemiology, biomarkers & prevention : a publication of the american association for cancer research, cosponsored by the american society of preventive oncology

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Abstract

MUC1 is a large, heavily glycosylated transmembrane glycoprotein that is proposed to create a protective microenvironment in many adenocarcinomas. Here we compare MUC1 and the well studied cell surface receptor target, EGFR, as gold nanoparticle (AuNP) targets and their subsequent vapor nanobubble generation efficacy in the human epithelial cell line, HES. Although EGFR and MUC1 were both highly expressed in these cells, TEM and confocal images revealed MUC1 as a superior target for nanoparticle intracellular accumulation and clustering. The MUC1-targeted AuNP intracellular clusters also generated significantly larger vapor nanobubbles. Our results demonstrate the promising opportunities MUC1 offers to improve the efficacy of targeted nanoparticle based approaches.

Reference Key
carson2012theranosticsthe Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Brian P. Danysh, Pamela E. Constantinou, Ekaterina Y. Lukianova-Hleb, Dmitri O. Lapotko, Daniel D. Carson
Journal cancer epidemiology, biomarkers & prevention : a publication of the american association for cancer research, cosponsored by the american society of preventive oncology
Year 2012
DOI
DOI not found
URL
http://www.thno.org/v02p0777.htm
Keywords
Medicine

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