resistance to taxanes in triple-negative breast cancer associates with the dynamics of a cd49f+ tumor-initiating population
Clicks: 332
ID: 240534
2017
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This
article has not been analysed, so there is no overall score —
reader engagement is measured and shown alongside.
Reader Engagement
Emerging Content
30.0
/100
332 views
50 readers
AI Quality Assessment
Not analyzed
Readership in this journal
EmergingRanked #11 of 101 articles by views in nature reviews gastroenterology & hepatology
Most read
Least read
Bar heights use a square-root scale.
Mint this article as an NFT
Not yet mintedCreate a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.
5
SUSD
one-off · no wallet required
Abstract
Taxanes are a mainstay of treatment for breast cancer, but resistance often develops followed by metastatic disease and mortality. Aiming to reveal the mechanisms underlying taxane resistance, we used breast cancer patient-derived orthoxenografts (PDX). Mimicking clinical behavior, triple-negative breast tumors (TNBCs) from PDX models were more sensitive to docetaxel than luminal tumors, but they progressively acquired resistance upon continuous drug administration. Mechanistically, we found that a CD49f+ chemoresistant population with tumor-initiating ability is present in sensitive tumors and expands during the acquisition of drug resistance. In the absence of the drug, the resistant CD49f+ population shrinks and taxane sensitivity is restored. We describe a transcriptional signature of resistance, predictive of recurrent disease after chemotherapy in TNBC. Together, these findings identify a CD49f+ population enriched in tumor-initiating ability and chemoresistance properties and evidence a drug holiday effect on the acquired resistance to docetaxel in triple-negative breast cancer.
| Reference Key |
gmez-miragaya2017stemresistance
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | ;Jorge Gómez-Miragaya;Marta Palafox;Laia Paré;Guillermo Yoldi;Irene Ferrer;Sergi Vila;Patricia Galván;Pasquale Pellegrini;Hector Pérez-Montoyo;Ana Igea;Purificación Muñoz;Manel Esteller;Angel R. Nebreda;Ander Urruticoechea;Idoia Morilla;Sonia Pernas;Fina Climent;María Teresa Soler-Monso;Ana Petit;Violeta Serra;Aleix Prat;Eva González-Suárez |
| Journal | nature reviews gastroenterology & hepatology |
| Year | 2017 |
| DOI |
10.1016/j.stemcr.2017.03.026
|
| URL | |
| Keywords |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.