treatment of severe malaria
Article Quality & Performance Metrics
Readership in this journal
PopularRanked #16 of 231 articles by views in planta medica
Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 231 in total.
Mint this article as an NFT
Not yet mintedCreate a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.
Abstract
Background. Malaria represents a medical emergency as it may rapidly progress to complication and death without a prompt and appropriate treatment. Severe malaria is almost exclusively caused by Plasmodium falciparum. The incidence of imported malaria in developed countries has been increasing and the case-fatality rate remains high despite progress in intensive care management and antimalarial treatment. Clinical deterioration usually appears 3 to 7 days after onset of fever. Complications involve the nervous, respiratory, renal and/or hematopoietic system. Acidosis and hypoglycemia are also common.
Conclusions. Intravenous quinine is the most widely used drug in the initial treatment of severe falciparum malaria whereas artemisinin derivatives are currently in developed countries recommended only for quinine-resistant cases. As soon as the patient is clinically stable and can swallow, oral treatment should be given. The intravascular volume should be maintained at the lowest level sufficient for adequate systemic perfusion to prevent development of acute respiratory distress syndrome. Renal replacement therapy in acute renal failure should be initiated early. Exchange blood transfusion has been suggested for the treatment of patients with severe malaria and hyperparasitemia. For the early diagnosis, it is of paramount importance to consider malaria in every febrile patient with a history of travel within an endemic area for the last years.
| Reference Key |
jereb2004zdravnikitreatment
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | ;Matjaž Jereb;Maja Bombek;Juš Kšela;Jasna Modrica Kobe;Igor Muzlovič;Andrej Trampuž |
| Journal | planta medica |
| Year | 2004 |
| DOI |
DOI not found
|
| URL | |
| Keywords |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.