genética molecular aplicada ao câncer cutâneo não melanoma molecular genetics of non-melanoma skin cancer

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ID: 240321
2006
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Abstract
Os cânceres cutâneos não melanoma são as neoplasias malignas mais comuns em humanos. O carcinoma basocelular e o carcinoma espinocelular representam cerca de 95% dos cânceres cutâneos não melanoma, o que os torna um crescente problema para a saúde p��blica mundial devido a suas prevalências cada vez maiores. As alterações genéticas que ocorrem no desenvolvimento dessas malignidades cutâneas são apenas parcialmente compreendidas, havendo muito interesse no conhecimento e determinação das bases genéticas dos cânceres cutâneos não melanoma que expliquem seus fenótipos, comportamentos biológicos e potenciais metastáticos distintos. Apresenta-se uma revisão atualizada da genética molecular aplicada aos cânceres cutâneos não melanoma, em especial ao carcinoma basocelular e carcinoma espinocelular, enfatizando os mais freqüentes genes e os principais mecanismos de instabilidade genômica envolvidos no desenvolvimento dessas malignidades cutâneas.
Non-melanoma skin cancers are the most common malignant neoplasms in humans. About 95% of all non-melanoma skin cancers are represented by basal cell carcinoma and squamous cell carcinoma. Their prevalences are still increasing worldwide, representing an important public health problem. The genetic alterations underlying basal cell carcinoma and squamous cell carcinoma development are only partly understood. Much interest lies in determining the genetic basis of non-melanoma skin cancers, to explain their distinctive phenotypes, biological behaviors and metastatic potential. We present here a molecular genetic update, focusing on the most frequent genes and genomic instability involved in the development and progression of non-melanoma skin cancers.
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Authors ;Marcos Antonio Rodrigues Martinez;Guilherme Francisco;Luciana Sanches Cabral;Itamar Romano Garcia Ruiz;Cyro Festa Neto
Journal Theriogenology
Year 2006
DOI
10.1590/S0365-05962006000500003
URL
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962006000500003
Keywords
skin neoplasms carcinoma basal cell squamous cell squamous cell skin neoplasms/geneticsdermatology

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