deregulated levels of the nf-κb1, nf-κb2, and rel genes in ukrainian patients with leukemia and lymphoma in the post-chernobyl period

Clicks: 273
ID: 240175
2016
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Abstract
Objective: Nuclear factor kappa B (NF-κB) is an important transcription factor in cancer and NF-κB activation has been seen in angiogenesis, tumor progression, and metastasis. Relationships between specific NF-κB gene networks, leukemogenesis, and radiation exposure are still unknown. Our aim was to study the expression levels of the NF-κB1, NF-κB2, and Rel genes in hematological malignancies in the post-Chernobyl period. Materials and Methods: We analyzed gene expression levels of NF- κB1, NF-κB2, and Rel in 49 B-cell chronic lymphocytic leukemia, 8 B-cell non-Hodgkin’s lymphoma, 3 acute myeloid leukemia, 3 chronic myeloid leukemia, 2 hairy cell leukemia, 2 myelodysplastic syndrome, and 2 T-cell large granular lymphocytic leukemia patients using realtime polymerase chain reaction. Results: Expression levels of NF-κB1, NF-κB2, and Rel genes were found to be deregulated. Conclusion: These results could be accepted as specific gene traces to radiation-induced leukemia or as potential candidates for new diagnostic biomarker studies. Larger experiments and non-exposed control malignant cell populations are needed to clarify these suggestions.
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savl2016turkishderegulated Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Hakan Savlı;Daniil F. Gluzman;Stella V. Koval
Journal proceedings of the international conference on iot in social, mobile, analytics and cloud, i-smac 2017
Year 2016
DOI
10.4274/tjh.2014.0190
URL
http://www.tjh.com.tr/jvi.aspx?pdir=tjh&plng=eng&un=TJH-90001&look4=
Keywords
Cancer myelodysplastic syndromes non-hodgkin’s lymphoma thrombosis chronic lymphocytic leukemia acute leukemia chronic leukemiainternal medicinediseases of the blood and blood-forming organs

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