elucidating duramycin’s bacterial selectivity and mode of action on the bacterial cell envelope

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ID: 240083
2018
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Ranked #455 of 875 articles by views in journal of magnetic resonance (san diego, calif : 1997)

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Abstract
The use of naturally occurring antimicrobial peptides provides a promising route to selectively target pathogenic agents and to shape microbiome structure. Lantibiotics, such as duramycin, are one class of bacterially produced peptidic natural products that can selectively inhibit the growth of other bacteria. However, despite longstanding characterization efforts, the microbial selectivity and mode of action of duramycin are still obscure. We describe here a suite of biological, chemical, and physical characterizations that shed new light on the selective and mechanistic aspects of duramycin activity. Bacterial screening assays have been performed using duramycin and Populus-derived bacterial isolates to determine species selectivity. Lipidomic profiles of selected resistant and sensitive strains show that the sensitivity of Gram-positive bacteria depends on the presence of phosphatidylethanolamine (PE) in the cell membrane. Further the surface and interface morphology were studied by high resolution atomic force microscopy and showed a progression of cellular changes in the cell envelope after treatment with duramycin for the susceptible bacterial strains. Together, these molecular and cellular level analyses provide insight into duramycin’s mode of action and a better understanding of its selectivity.
Reference Key
hasim2018frontierselucidating Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Sahar Hasim;Sahar Hasim;David P. Allison;David P. Allison;Berlin Mendez;Abigail T. Farmer;Dale A. Pelletier;Scott T. Retterer;Scott T. Retterer;Shawn R. Campagna;Todd B. Reynolds;Mitchel J. Doktycz;Mitchel J. Doktycz
Journal journal of magnetic resonance (san diego, calif : 1997)
Year 2018
DOI
10.3389/fmicb.2018.00219
URL
http://journal.frontiersin.org/article/10.3389/fmicb.2018.00219/full
Keywords
lipid atomic force microscopy (afm)

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