complement in kidney transplantation

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ID: 240077
2017
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Abstract
The complement system is considered to be an important part of innate immune system with a significant role in inflammation processes. The activation can occur through classical, alternative, or lectin pathway, resulting in the creation of anaphylatoxins C3a and C5a, possessing a vast spectrum of immune functions, and the assembly of terminal complement cascade, capable of direct cell lysis. The activation processes are tightly regulated; inappropriate activation of the complement cascade plays a significant role in many renal diseases including organ transplantation. Moreover, complement cascade is activated during ischemia/reperfusion injury processes and influences delayed graft function of kidney allografts. Interestingly, complement system has been found to play a role in both acute cellular and antibody-mediated rejections and thrombotic microangiopathy. Therefore, complement system may represent an interesting therapeutical target in kidney transplant pathologies.
Reference Key
cernoch2017frontierscomplement Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Marek Cernoch;Ondrej Viklicky;Ondrej Viklicky
Journal Stroke
Year 2017
DOI
10.3389/fmed.2017.00066
URL
http://journal.frontiersin.org/article/10.3389/fmed.2017.00066/full
Keywords
complement kidney transplantation ischemia/reperfusion injury anticomplement therapymedicine (general)

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