efficacy of ivermectin against the bloodsucking insect, rhodnius prolixus (hemiptera, triatominae)

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ID: 239976
1985
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Abstract
Ivermectin (0.2 mg/kg body weight) caused a high mortality in nymphs and adults of Rhodnius prolixus following a single meal in mice sub-cutaneously injected with the drug. This effect was more evident in nymphs of 1st-and 2nd-instar than in older nymphs and adults. Third-instar nymphs presented a high mortality when fed on mice treated with ivermectin 24 and 48 hours previously, while mortality was significantly reduced in nymphs fed on mice treated 72 hours before. Surviving 3rd-instar nymphs did not molt. When adult females were fed once on mice treated for 24 hours with ivermectin there was a considerable reduction in egg production. This inhibition was not reversed by a second feeding on normal mice. We concluded that sub-lethal doses of ivermectin caused toxic effects interfering in the neuro-endocrine control of development and reproduction of this bloodsucking insect.
A alimentação de ninfas e adultos de Rhodnius prolixus em camundongos tratados previamente com ivermectin (0,2 mg/kg peso corporal, via subcutânea) resultou em alta mortalidade dos insetos. Este efeito foi mais drástico em ninfas de 1º e 2º estádios. Foi observado que as ninfas de 3º estádio alimentadas 24-48 horas após o tratamento dos camundongos demonstraram uma mortalidade maior do que os insetos alimentados 72 horas após o tratamento. Os insetos de 3º estádio sobreviventes aos tratamentos apresentaram uma inibição total das mudas. Fêmeas adultas alimentadas em camundongos 24 horas após o tratamento com invermectin demonstraram uma considerável redução na produção de ovos. Este efeito não foi revertido por uma posterior alimentação em camundongos normais. Foi sugerido que dose subletal de ivermectin poderia interferir no controle neuro-endócrino do desenvolvimento e reprodução do inseto.
Reference Key
azambuja1985memriasefficacy Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Patricia de Azambuja;José Eugenio P. Lima Gomes;Fernando Lopes;Eloi S. Garcia
Journal kurdistan journal of applied research
Year 1985
DOI
10.1590/S0074-02761985000400009
URL
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761985000400009
Keywords
hemiptera ivermectin tropical medicinemicrobiology

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