modelo experimental de perfusão pulmonar isolada em ratos: técnica e aplicações em estudos de preservação pulmonar experimental model of isolated lung perfusion in rats: technique and application in lung preservation studies

Clicks: 309
ID: 239946
2010
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Abstract
Estudos de preservação pulmonar em modelos experimentais realizados em animais de pequeno porte são de realização mais simples e barata. Esta comunicação tem o enfoque de descrever tecnicamente um modelo de perfusão pulmonar ex vivo em ratos, com o uso de um equipamento disponível comercialmente que foi o primeiro a ser instalado em um laboratório de pesquisa em cirurgia torácica no Brasil. Descrevemos detalhadamente o modelo e sua preparação, assim como suas aplicações para estudos de preservação pulmonar. Os detalhes técnicos da preparação podem ser observados também em um vídeo postado no site do Jornal Brasileiro de Pneumologia.
Small animal models are particularly suitable for lung preservation studies, because they are simple and cost-effective. This brief communication focuses on the technical description of an ex vivo lung perfusion model in rats by means of a commercially available apparatus, which was the first to be installed in a thoracic surgery research laboratory in Brazil. The model and its preparation, together with its applications for lung preservation studies, are described in detail. All technical details can also be seen in a video posted on the website of the Brazilian Journal of Pulmonology.
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pgo-fernandes2010jornalmodelo Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Paulo Manuel Pêgo-Fernandes;Eduardo de Campos Werebe;Paulo Francisco Guerreiro Cardoso;Rogério Pazetti;Karina Andrighetti de Oliveira;Paula Roberta Otaviano Soares;Fabio Biscegli Jatene
Journal cryobiology
Year 2010
DOI
10.1590/S1806-37132010000400015
URL
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132010000400015
Keywords
rats lung transplantation models reperfusion injury traumatismo por reperfusão

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