stdp in the developing sensory neocortex

Clicks: 326
ID: 239815
2010
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Abstract
Spike timing-dependent plasticity (STDP) has been proposed as a mechanism for optimizing the tuning of neurons to sensory inputs, a process that underlies the formation of receptive field properties and associative memories. The properties of STDP must adjust during development to enable neurons to optimally tune their selectivity for environmental stimuli, but these changes are poorly understood. Here we review the properties of STDP and how these may change during development in primary sensory cortical layers 2/3 and 4, initial sites for intracortical processing. We provide a primer discussing postnatal developmental changes in synaptic proteins and neuromodulators that are thought to influence STDP induction and expression. We propose that STDP is shaped by, but also modifies, synapses to produce refinements in neuronal responses to sensory inputs.
Reference Key
larsen2010frontiersstdp Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Rylan S Larsen;Deepti Rao;Paul B Manis;Paul B Manis;Paul B Manis;Paul B Manis;Benjamin D Philpot;Benjamin D Philpot;Benjamin D Philpot;Benjamin D Philpot
Journal Diabetes
Year 2010
DOI
10.3389/fnsyn.2010.00009
URL
http://journal.frontiersin.org/Journal/10.3389/fnsyn.2010.00009/full
Keywords
neuromodulation visual cortex auditory cortex endocannabinoid somatosensory cortex neuropsychiatry biological psychiatry presynaptic nmda receptorneurosciences

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