lactic acidosis in prostate cancer: consider the warburg effect

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ID: 239649
2017
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Abstract
Lactic acidosis is a commonly observed clinical condition that is associated with a poor prognosis, especially in malignancies. We describe a case of an 81-year-old patient who presented with symptoms of tachypnea and general discomfort. Arterial blood gas analysis showed a high anion gap acidosis with a lactate level of 9.5 mmol/L with respiratory compensation. CT scanning showed no signs of pulmonary embolism or other causes of impaired tissue oxygenation. Despite treatment with sodium bicarbonate, the patient developed an adrenalin-resistant cardiac arrest, most likely caused by the acidosis. Autopsy revealed Gleason score 5 + 5 metastatic prostate cancer as the most probable cause of the lactic acidosis. Next-generation sequencing indicated a nonsense mutation in the TP53 gene (887delA) and an activating mutation in the PIK3CA gene (1634A>G) as candidate molecular drivers. This case demonstrates the prevalence and clinical relevance of metabolic reprogramming, frequently referred to as “the Warburg effect,” in patients with prostate cancer.
Reference Key
van der mijn2017caselactic Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Johannes C. van der Mijn;Mathijs J. Kuiper;Carl E.H. Siegert;Annabeth E. Wassenaar;Carel J.M. van Noesel;Aernout C. Ogilvie
Journal multi-span large bridges - proceedings of the international conference on multi-span large bridges, 2015
Year 2017
DOI
10.1159/000485242
URL
https://www.karger.com/Article/FullText/485242
Keywords
mutation prostate cancer warburg effect metabolic reprogramming p53 mutations Oncology including cancer and carcinogens tumors case reportneoplasms idh1 mutations

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