pró-fármaco ativado por enzima, uma estratégia promissora na quimioterapia
Clicks: 275
ID: 239304
2006
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Abstract
Strategies that promote selective activation of prodrugs by enzymes can be divided into two major classes: 1) deliver of a monoclonal antibody-enzyme immunoconjugate that can recognize a specific antigen and promote the prodrug to a citotoxic drug, with a high selectivity for the target cells, and 2) selective gene delivery encoding an enzyme that can promote the prodrug to a citotoxic drug for the target cells. In this article are discussed ADEPT (antibody-directed enzyme prodrug therapy), GDEPT (gene-directed enzyme prodrug therapy), VDEPT (virus-directed enzyme prodrug therapy), GPAT (genetic prodrug activation therapy) and PDEPT (polymer-directed enzyme prodrug therapy) approaches, their clinical trials, advantages, disadvantages and perspectives.
| Reference Key |
blau2006qumicapr-frmaco
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|---|---|
| Authors | ;Lorena Blau;Renato Farina Menegon;Man Chin Chung |
| Journal | greece and rome |
| Year | 2006 |
| DOI |
10.1590/S0100-40422006000600028
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| URL | |
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