estudo do comportamento de cepas de trypanosoma cruzi após passagem em diferentes espécies de triatomíneos
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ID: 239291
1991
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Abstract
Foi estudada a influência da passagem em diferentes espécies de triatomíneos de cepas do T. cruzi biologicamente distintas, mantidas em camundongos. Cepas: Peruana (Tipo I), 12 SF (Tipo II), Colombiana (Tipo 111). Triatomíneos: Rhodnius prolixus, Panstrongylus megistus e Triatoma infestans. Ninfas do 4o estágio foram alimentadas em camundongos infectados com as respectivas cepas e obtidos os inóculos (icft formas metacíclinas) para infecção de camundongos de 8 a 10 g. Grupos experimentais para cada cepa: I - Controles inoculados com formas sanguícolas; 11,111 e TV - inoculados com metacíclicos de P. megistus, T. infestans ou R. prolixus, respectivamente. Os perfis de parasitemia foram mantidos para cada cepa, com piques mais elevados nas infecções com metacíclicos do P. megistus e do R. prolixus, para a cepa Peruana, do P. megistus para a 12 SF e do R. prolixus, para a Colombiana. O histotropismo e o padrão de lesões foram mantidos para os três tipos de cepas. O grau de virulência da cepa Peruana foi idêntico em todos os grupos e variou para as cepas 12 SF e Colombiana de acordo com a espécie de triatomíneo usada, com predominância deformas delgadas, nos inoculados com formas metacíclicos o que foi interpretado como uma fase adaptativa das formas metacíclicos ao hospedeiro vertebrado.
To study the injluence ofthe intermediate host stage on the course of mouse infection, Trypanosoma cruzi belonging to the Peruvian (Type I), 12 SF (Type II) and Colombian (Type 111) strains were passaged through either Rhodnius prolixus, Panstrongylus megistus or Triatoma infestans. T. cruzimetacyclicforms (dose 10*) from the different strains were obtained from each bug and inoculated into 8-10 gm mice. Comparison was made in mice inoculated with bloodforms. Parasitaemia curves were plotted in the peripheral blood for each strain, reaching more elevated peaks with Peruvian strain parasites from P. megistus and R. prolixus, 12 SF strain from P. megistus and Colombian strain from R. prolixus. Tissue tropism and histopathologiealpatterns were those usually seen in mice infected with each respective strain type. Peruvian virulence was the same for all groups. Slender forms predominate among mice inoculated with metacy clic forms of Colombian and 12 SF strains, probably an adaptative parasite change related to the intermediate host.
To study the injluence ofthe intermediate host stage on the course of mouse infection, Trypanosoma cruzi belonging to the Peruvian (Type I), 12 SF (Type II) and Colombian (Type 111) strains were passaged through either Rhodnius prolixus, Panstrongylus megistus or Triatoma infestans. T. cruzimetacyclicforms (dose 10*) from the different strains were obtained from each bug and inoculated into 8-10 gm mice. Comparison was made in mice inoculated with bloodforms. Parasitaemia curves were plotted in the peripheral blood for each strain, reaching more elevated peaks with Peruvian strain parasites from P. megistus and R. prolixus, 12 SF strain from P. megistus and Colombian strain from R. prolixus. Tissue tropism and histopathologiealpatterns were those usually seen in mice infected with each respective strain type. Peruvian virulence was the same for all groups. Slender forms predominate among mice inoculated with metacy clic forms of Colombian and 12 SF strains, probably an adaptative parasite change related to the intermediate host.
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magalhes1991revistaestudo
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| Authors | ;Juracy B. Magalhães;Sonia G. Andrade |
| Journal | mobile information systems |
| Year | 1991 |
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