the pleiotropic effects of paricalcitol: beyond bone-mineral metabolism

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ID: 239279
2016
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Abstract
Secondary hyperparathyroidism (SHPT) is a common complication in patients with chronic kidney disease (CKD) that is characterised by elevated parathyroid hormone (PTH) levels and a series of bone-mineral metabolism anomalies. In patients with SHPT, treatment with paricalcitol, a selective vitamin D receptor activator, has been shown to reduce PTH levels with minimal serum calcium and phosphorus variations. The classic effect of paricalcitol is that of a mediator in mineral and bone homeostasis. However, recent studies have suggested that the benefits of treatment with paricalcitol go beyond PTH reduction and, for instance, it has a positive effect on cardiovascular disease and survival. The objective of this study is to review the most significant studies on the so-called pleiotropic effects of paricalcitol treatment in patients with CKD.
Reference Key
egido2016nefrologathe Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Jesús Egido;Alberto Martínez-Castelao;Jordi Bover;Manuel Praga;José Vicente Torregrosa;Elvira Fernández-Giráldez;Carlos Solozábal
Journal demiryolu mühendisliği
Year 2016
DOI
10.1016/j.nefroe.2016.02.006
URL
http://www.sciencedirect.com/science/article/pii/S2013251416000274
Keywords
dialysis vitamin d atherosclerosis proteinuria vascular calcification parathyroid hormone secondary hyperparathyroidism urology

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