briaviolides k–n, new briarane-type diterpenoids from cultured octocoral briareum violaceum

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ID: 239045
2018
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Abstract
Four new briarane diterpenoids, briaviolides K–N (1–4), have been obtained from the cultured-type octocoral Briareum violaceum. Using a spectroscopic approach, the structures of briaranes 1–4 were identified. This study employed an in vitro model of lipopolysaccharide (LPS)-induced inflammation in the murine macrophage RAW 264.7 cell line, and found that among the four briaranes, briarane 2 possessed anti-inflammatory activity against inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) protein expressions in cells. In addition, principal component analysis using the chemical global positioning system (ChemGPS) for natural products (ChemGPS-NP) was employed in order to analyze the structure-activity relationship (SAR), and the results indicated that the ring conformation of the compound has a leading role in suppressing the expressions of pro-inflammatory iNOS and COX-2 proteins in macrophages.
Reference Key
xu2018marinebriaviolides Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Jing-Hao Xu;Kuei-Hung Lai;Yin-Di Su;Yu-Chia Chang;Bo-Rong Peng;Anders Backlund;Zhi-Hong Wen;Ping-Jyun Sung
Journal jixie gongcheng xuebao/journal of mechanical engineering
Year 2018
DOI
10.3390/md16030075
URL
http://www.mdpi.com/1660-3397/16/3/75
Keywords
inos cox-2 chemgps-npbiology (general)

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