potential of caveolae in the therapy of cardiovascular and neurological diseases

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ID: 238787
2014
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Abstract
Caveolae are membrane micro-domains enriched in cholesterol, sphingolipids and caveolins, which are transmembrane proteins with hairpin-like structure. Caveolae participate in receptor-mediated trafficking of cell surface receptors and receptor-mediated signaling. Furthermore, caveolae participate in clathrin-independent endocytosis of membrane receptors. On the one hand, caveolins are involved in vascular and cardiac dysfunction. Also, neurological abnormalities in caveolin-1 knockout mice and a link between caveolin-1 gene haplotypes and neurodegenerative diseases have been reported. The aim of this article is to present the rationale for considering caveolae as potential targets in cardiovascular and neurological diseases.
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enavarro2014frontierspotential Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Gemma eNavarro;Kjell eFuxe;Dasiel Oscar Borroto-Escuela;Rafael eFranco
Journal Journal of clinical and experimental dentistry
Year 2014
DOI
10.3389/fphys.2014.00370
URL
http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00370/full
Keywords
microrna cell therapy gene therapy endothelium down-regulation

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