novel fluoroquinolone derivatives bearing n-thiomide linkage with 6-substituted-2-aminobenzothiazoles: synthesis and antibacterial evaluation

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ID: 238751
2017
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Abstract
A series of novel fluoroquinolone derivatives bearing N-thiomide linkage with 6-substituted-2-aminobenzothiazole substituents at the C-7 position were synthesized to obtain potent analogs active against bacterial strains. Some compounds exhibited excellent antibacterial activity against Staphylococcus auerus, Escherichia coli, Bacillus subtilis, Pseudomonas aeruginosa bacterial strains. Among all the synthesized compounds 6-nitro substituted benzothiazole along with norfloxacin (4b) and gatifloxacin (4l) showed MIC 05 μg/ml when tested against S. auerus. Moreover, compounds 4d, 4f and 4l showed superior MIC (15, 10, and 15 μg/ml respectively) against B. subtilis. The results of the present study reveal that the compounds have significant antibacterial potential and are suitable candidates for further exploration.
Reference Key
sharma2017arabiannovel Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Prabodh Chander Sharma;Ankit Jain;Mohammad Shahar Yar;Rakesh Pahwa;Jasbir Singh;Preeti Chanalia
Journal Behavioural brain research
Year 2017
DOI
10.1016/j.arabjc.2012.11.002
URL
http://www.sciencedirect.com/science/article/pii/S1878535212002493
Keywords
antibacterial benzothiazole fluoroquinolone

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