association of single nucleotide polymorphisms in the il-18 gene with production of il-18 protein by mononuclear cells from healthy donors
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ID: 238516
2008
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Abstract
IL-18 has proinflammatory effects and participates in both innate and adaptive cellular and humoral immunity. A number of SNPs that influence IL-18 production are found in the gene promoter region. We investigated the association of SNPs in the IL-18 promoter at −607 and −137 with the level of IL-18 protein production by PBMC from healthy donors from Southwestern Siberia. The genetic distribution of these SNPs in the promoter site was established by PCR. IL-18 protein production was determined by ELISA. Our results showed that PBMC from donors carrying allele 137C have lower levels of both spontaneous and LPS-stimulated IL-18 production. In contrast, PBMC from donors carrying allele 607A showed significant increases in spontaneous and stimulated IL-18 production compared to wild type. Our study suggests that the SNPs −607 and −137 in the promoter region of the IL-18 gene influence the level of IL-18 protein production by PBMC from healthy donors in Southwestern Siberia.
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pavlovna2008mediatorsassociation
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| Authors | ;Khripko Olga Pavlovna;Sennikova Nadegda Sergeevna;Lopatnikova Julia Anatolievna;Khripko Jurii Ivanovich;Filipenko Maxim Leonidovich;Khrapov Evgenii Alexandrovich;Gelfgat Evgenii L'vovich;Yakushenko Elena Vladimirovna;Kozlov Vladimir Alexandrovich;Sennikov Sergei Vitalievich |
| Journal | polyhedron |
| Year | 2008 |
| DOI |
10.1155/2008/309721
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| URL | |
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