ameliorative potential of butea monosperma on chronic constriction injury of sciatic nerve induced neuropathic pain in rats

Clicks: 269
ID: 238322
2012
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Steady

Ranked #41 of 122 articles by views in hypertension (dallas, tex : 1979)

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 122 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
The present study was designed to investigate the ameliorative role of ethanolic extract from leaves of Butea monosperma in chronic constriction injury (CCI) of sciatic nerve induced neuropathic pain in rats. Hot plate, acetone drop, paw pressure, Von Frey hair and tail immersion tests were performed to assess the degree of thermal hyperalgesia, cold chemical allodynia, mechanical hyperalgesia & allodynia in the left hind paw and tail thermal hyperalgesia. Further on, thiobarbituric acid reactive substances (TBARS), reduced glutathione (GSH) and total calcium levels were estimated to assess the biochemical changes in the sciatic nerve tissue. Histopathological changes were also observed in the sciatic nerve tissue. Ethanolic extract of Butea monosperma leaves and pregabalin (serving as positive control) were administered for 14 consecutive days starting from the day of surgery. CCI resulted in significant changes in behavioural and biochemical parameters. Pretreatment of Butea monosperma attenuated CCI induced development of behavioural, biochemical and histopathological alterations in a dose dependent manner, which is comparable to that of pregabalin pretreated group. These findings may be attributed to its potential anti-oxidative, neuroprotective and calcium channel modulatory actions of Butea monosperma.
O presente trabalho visou investigar o papel do extrato etanólico de folhas de Butea monosperma no alívio da dor neuropática pela injúria de constrição crônica (CCI) do nervo ciático induzida em ratos. Placa quente, gota de acetona, pressão na pata, testes de imersão de pelo e cauda de Von Frey foram utilizados para acessar o grau de hiperalgesia térmica, alodinia química fria, hiperalgesia mecânica e alodinia na pata trazeira esquerda e hiperalgesia térmica da cauda. Além disso, substâncias reativas com ácido tiobarbitúrico (TBARS), glutatião reduzido (GSH) e níveis de cálcio total foram estimados para acessar as alterações bioquímicas no tecido do nervo ciático. Alterações histopatológicas foram também observadas no tecido do nervo ciático. O extrato etanólico das folhas de Butea monosperma e pregabalina (servindo de controle positivo) foram administrados por 14 dias consecutivos, iniciando-se no dia da cirurgia. CCI resultou em alterações significativas nos parâmetros comportamentais e bioquímicos. Pretratamento com Butea monosperma atenuou o desenvolvimento das alterações comportamentais, bioquímicas e histopatológicas induzidas pela CCI de maneira dose dependente, comparável ao grupo pretratado com pregabalina. Esses resultados podem ser atribuídos ao potencial antioxidativo, neuroprotetor e às ações modulatórias de canais de cálcio da Butea monosperma.
Reference Key
thiagarajan2012anaisameliorative Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Venkata R.K. Thiagarajan;Palanichamy Shanmugam;Uma M. Krishnan;Arunachalam Muthuraman;Nirmal Singh
Journal hypertension (dallas, tex : 1979)
Year 2012
DOI
DOI not found
URL
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652012000400023
Keywords
anti-oxidant calcium reduced glutathione

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.