pseudonocardians a–c, new diazaanthraquinone derivatives from a deap-sea actinomycete pseudonocardia sp. scsio 01299
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ID: 238299
2011
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Abstract
Pseudonocardians A–C (2–4), three new diazaanthraquinone derivatives, along with a previously synthesized compound deoxynyboquinone (1), were produced by the strain SCSIO 01299, a marine actinomycete member of the genus Pseudonocardia, isolated from deep-sea sediment of the South China Sea. The structures of compounds 1–4 were determined by mass spectrometry and NMR experiments (1H, 13C, HSQC, and HMBC). The structure of compound 1, which was obtained for the first time from a natural source, was confirmed by X-ray analysis. Compounds 1–3 exhibited potent cytotoxic activities against three tumor cell lines of SF-268, MCF-7 and NCI-H460 with IC50 values between 0.01 and 0.21 μm, and also showed antibacterial activities on Staphylococcus aureus ATCC 29213, Enterococcus faecalis ATCC 29212 and Bacillus thuringensis SCSIO BT01, with MIC values of 1–4 μg mL−1.
| Reference Key |
yang2011marinepseudonocardians
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| Authors | ;Xianwen Yang;Changsheng Zhang;Jianhua Ju;Wenjun Li;Weimin Zhang;Haibo Zhang;Yuchan Chen;Wenjun Zhang;Xinpeng Tian;Siwen Niu;Sumei Li;Si Zhang |
| Journal | jixie gongcheng xuebao/journal of mechanical engineering |
| Year | 2011 |
| DOI |
10.3390/md9081428
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| URL | |
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