Biomimetic Enantioselective Total Synthesis of (-)-Robustanoids A and B and Analogues.
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2019
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Abstract
We report a step-economical, enantioselective total synthesis of (-)-robustanoid B and (-)-robustanoid A and four novel natural product-like compounds. Our strategy relied on our biosynthetic hypothesis and on a novel complexity generation methodology, namely, the one-pot hydroxylative double cyclization reaction. The latter consists of a modified 3,3-dimethyldioxirane-triggered epoxidation-epoxide-ring-opening cyclization reaction cascade and Trost's regioselectivity umpolung methodology ("anti-Michael addition").
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| Authors | Liu, Zhan-Jiang;Huang, Pei-Qiang; |
| Journal | The Journal of organic chemistry |
| Year | 2019 |
| DOI |
10.1021/acs.joc.9b00573
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