radiation- and photo-induced activation of 5-fluorouracil prodrugs as a strategy for the selective treatment of solid tumors

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ID: 238141
2008
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Abstract
5-Fluorouracil (5-FU) is used widely as an anticancer drug to treat solid cancers, such as colon, breast, rectal, and pancreatic cancers, although its clinical application is limited because 5-FU has gastrointestinal and hematological toxicity. Many groups are searching for prodrugs with functions that are tumor selective in their delivery and can be activated to improve the clinical utility of 5-FU as an important cancer chemotherapeutic agent. UV and ionizing radiation can cause chemical reactions in a localized area of the body, and these have been applied in the development of site-specific drug activation and sensitization. In this review, we describe recent progress in the development of novel 5-FU prodrugs that are activated site specifically by UV light and ionizing radiation in the tumor microenvironment. We also discuss the chemical mechanisms underlying this activation.
Reference Key
nishimoto2008moleculesradiation- Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Sei-ichi Nishimoto;Hiroshi Hatta;Hisatsugu Yamada;Kazuhito Tanabe;Takeo Ito
Journal Journal of ethnopharmacology
Year 2008
DOI
DOI not found
URL
http://www.mdpi.com/1420-3049/13/10/2370/
Keywords
Hypoxia 5-fluorouracil prodrugs photolysisorganic chemistry

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