neutralization interfering antibodies: a “novel” example of humoral immune dysfunction facilitating viral escape?
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ID: 237930
2012
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Abstract
The immune response against some viral pathogens, in particular those causing chronic infections, is often ineffective notwithstanding a robust humoral neutralizing response. Several evasion mechanisms capable of subverting the activity of neutralizing antibodies (nAbs) have been described. Among them, the elicitation of non-neutralizing and interfering Abs has been hypothesized. Recently, this evasion mechanism has acquired an increasing interest given its possible impact on novel nAb-based antiviral therapeutic and prophylactic approaches. In this review, we illustrate the mechanisms of Ab-mediated interference and the viral pathogens described in literature as able to adopt this “novel” evasion strategy.
| Reference Key |
burioni2012virusesneutralization
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|---|---|
| Authors | ;Roberto Burioni;Laura Solforosi;Massimo Clementi;Roberta A. Diotti;Matteo Castelli;Elena Criscuolo;Nicola Clementi;Giuseppe Sautto;Mancini Nicasio |
| Journal | International journal of pharmaceutics |
| Year | 2012 |
| DOI |
10.3390/v4091731
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| URL | |
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