severe rhabdomyolysis associated with simvastatin and role of ciprofloxacin and amlodipine coadministration

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ID: 237817
2015
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Abstract
Simvastatin is among the most commonly used prescription medications for cholesterol reduction and the most common statin-related adverse drug reaction is skeletal muscle toxicity. Multiple factors have been shown to influence simvastatin-induced myopathy. In addition to age, gender, ethnicity, genetic predisposition, and dose, drug-drug interactions play a major role. This is particularly true for drugs that are extensively metabolized by cytochrome P450 (CYP)3A4. We describe a particularly severe case of rhabdomyolysis after the introduction of ciprofloxacin, a weak CYP3A4 inhibitor, in a patient who previously tolerated the simvastatin-amlodipine combination.
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schryver2015casesevere Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Nicolas De Schryver, Xavier Wittebole, Peter Van den Bergh, Vincent Haufroid, Eric Goffin, Philippe Hantson
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Journal molecular nutrition and food research
Year 2015
DOI
10.1155/2015/761393
URL
http://dx.doi.org/10.1155/2015/761393
Keywords
diseases of the genitourinary system urology

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