fatores de risco para aterosclerose em crianças e adolescentes com história familiar de doença arterial coronariana prematura risk factors for atherosclerosis in children and adolescents with family history of premature coronary artery disease

Clicks: 319
ID: 237815
2004
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Abstract
OBJETIVOS: Analisar a prevalência de dislipidemia em 109 crianças e adolescentes com história familiar de doença arterial coronariana prematura e a associação com outros fatores de risco para aterosclerose. MÉTODOS: Foram determinados valores séricos de colesterol total, de lipoproteínas de baixa densidade (LDL-C), alta densidade (HDL-C), triglicérides, índice de massa corpórea e pressão arterial. Foram também avaliados: prática de atividade física, tabagismo, renda familiar e escolaridade da mãe. RESULTADOS: Do total, 27,5 e 19,3% apresentaram, respectivamente, valores de colesterol total e LDL-C acima do normal, 13,8% valores de HDL-C diminuídos e 13,0% trigliceridemia elevada. Excesso de peso (obesidade e sobrepeso) foi detectado em 25,7% dos casos; destes, 57,1% apresentavam valores anormais de lipídios. A prevalência de dislipidemia, isolada ou concomitante com outros fatores de risco, foi de 38,5%. Hábito de fumar ocorreu em 3,6% dos casos, hipertensão arterial em 2,7%, e 72,5% não praticavam atividade física. Não houve associação entre as variáveis renda familiar, escolaridade da mãe e prática de atividade física e dislipidemia. Entretanto, observou-se associação significativa entre dislipidemia e excesso de peso (p = 0,02; odds ratio = 2,82; IC 95% = 1,16-6,81). CONCLUSÃO: Fatores de risco para aterosclerose em crianças e adolescentes com história familiar de doença arterial coronariana prematura devem ser identificados o mais cedo possível para que sejam adotados programas preventivos de saúde.
OBJECTIVES: To identify the prevalence of dyslipidemia in a group of 109 children and adolescents with a family history of premature coronary artery disease and to investigate the association between dyslipidemia and other risk factors for atherosclerosis. METHODS: Total cholesterol, low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), triglycerides, body mass index, blood pressure, physical activity, smoking, per capita income and maternal schooling were investigated. RESULTS: Total cholesterol and LDL-C levels were higher than desirable in 27.5% and 19.3%, respectively, of our patients; 13.8% had lower HDL-C values and 13.0% presented hypertriglyceridemia. Obesity and excess weight were observed in 25.7% of the cases. Out of these, 57.1% had abnormal lipid values. Dyslipidemia was observed in 38.5%, either alone or in combination with other risk factors. Smoking was observed in 3.6%, hypertension in 2.7% and physical inactivity in 72.5%. There was no relationship between dyslipidemia and per capita income, maternal schooling and physical inactivity. However, obesity and excess weight were identified as significantly associated with the occurrence of dyslipidemia (p = 0.02; odds ratio = 2.82, 95% CI = 1.6-6.81). CONCLUSION: In children and adolescents with a family history of premature coronary artery disease, early identification of the risk factors for atherosclerosis is essential to allow the implementation of preventive measures.
Reference Key
romaldini2004jornalfatores Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Ceres C. Romaldini;Hugo Issler;Ary L. Cardoso;Jayme Diament;Neusa Forti
Journal sports (basel, switzerland)
Year 2004
DOI
10.1590/S0021-75572004000200011
URL
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572004000200011
Keywords
atherosclerosis coronary artery disease dyslipidemia hypercholesterolemia lipoproteinspediatrics

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