amylose-based cationic star polymers for sirna delivery
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ID: 237411
2015
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Abstract
A new siRNA delivery system using a cationic glyco-star polymer is described. Spermine-modified 8-arm amylose star polymer (with a degree of polymerization of approximately 60 per arm) was synthesized by chemoenzymatic methods. The cationic star polymer effectively bound to siRNA and formed spherical complexes with an average hydrodynamic diameter of 230 nm. The cationic 8-arm star polymer complexes showed superior cellular uptake characteristics and higher gene silencing effects than a cationic 1-arm polymer. These results suggest that amylose-based star polymers are a promising nanoplatform for glycobiomaterials.
| Reference Key |
nishimura2015biomedamylose-based
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|---|---|
| Authors | ;Tomoki Nishimura;Kaori Umezaki;Sada-atsu Mukai;Shin-ichi Sawada;Kazunari Akiyoshi |
| Journal | spectrochimica acta - part a: molecular and biomolecular spectroscopy |
| Year | 2015 |
| DOI |
10.1155/2015/962941
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