bci performance and brain metabolism profile in severely brain-injured patients without response to command at bedside

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ID: 237049
2018
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Abstract
Detection and interpretation of signs of “covert command following” in patients with disorders of consciousness (DOC) remains a challenge for clinicians. In this study, we used a tactile P3-based BCI in 12 patients without behavioral command following, attempting to establish “covert command following.” These results were then confronted to cerebral metabolism preservation as measured with glucose PET (FDG-PET). One patient showed “covert command following” (i.e., above-threshold BCI performance) during the active tactile paradigm. This patient also showed a higher cerebral glucose metabolism within the language network (presumably required for command following) when compared with the other patients without “covert command-following” but having a cerebral glucose metabolism indicative of minimally conscious state. Our results suggest that the P3-based BCI might probe “covert command following” in patients without behavioral response to command and therefore could be a valuable addition in the clinical assessment of patients with DOC.
Reference Key
annen2018frontiersbci Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Jitka Annen;Séverine Blandiaux;Nicolas Lejeune;Nicolas Lejeune;Nicolas Lejeune;Mohamed A. Bahri;Aurore Thibaut;Woosang Cho;Christoph Guger;Christoph Guger;Camille Chatelle;Camille Chatelle;Steven Laureys
Journal Journal of enzyme inhibition and medicinal chemistry
Year 2018
DOI
10.3389/fnins.2018.00370
URL
https://www.frontiersin.org/article/10.3389/fnins.2018.00370/full
Keywords
p3 consciousness disorders of consciousness neuropsychiatry biological psychiatry

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