imaging of cerebral blood flow in patients with severe traumatic brain injury in the neurointensive care.

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ID: 236915
2014
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Abstract
Ischemia is a common and deleterious secondary injury following traumatic brain injury (TBI). A great challenge for the treatment of TBI patients in the neurointensive care unit (NICU) is to detect early signs of ischemia in order to prevent further advancement and deterioration of the brain tissue. Today, several imaging techniques are available to monitor cerebral blood flow (CBF) in the injured brain such as Positron emission tomography (PET), Single-photon emission computed tomography (SPECT), Xenon-CT, perfusion weighted magnetic resonance imaging (MRI) and CT perfusion scan. An ideal imaging technique would enable continuous noninvasive measurement of blood flow and metabolism across the whole brain. Unfortunately, no current imaging method meets all these criteria. These techniques offer snapshots of the CBF. MRI may also provide some information about the metabolic state of the brain. PET provides images with high resolution and quantitative measurements of CBF and metabolism however it is a complex and costly method limited to few TBI centres. All of these methods except mobile Xenon-CT require transfer of TBI patients to the radiological department. Mobile Xenon-CT emerges as a feasible technique to monitor CBF in the NICU, with lower risk of adverse effects. Promising results have been demonstrated with Xenon-CT in predicting outcome in TBI patients. This review covers available imaging methods used to monitor CBF in patients with severe TBI.
Reference Key
erostami2014frontiersimaging Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Elham eRostami;Elham eRostami;Henrik eEngquist;Per eEnblad
Journal journal of photochemistry and photobiology a: chemistry
Year 2014
DOI
10.3389/fneur.2014.00114
URL
http://journal.frontiersin.org/Journal/10.3389/fneur.2014.00114/full
Keywords
imaging brain injury perfusion imaging cerebral blood flow positron-emission tomography diseases of the nervous system

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