antiviral activity of agaricus blazei murrill ss. heinem extract against human and bovine herpesviruses in cell culture inibição da replicação de herpes vírus humano e bovino pelo extrato de agaricus blazei murrill ss. heinem em cultura de células

Clicks: 271
ID: 236480
2006
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Abstract
The aqueous extract of Agaricus blazei Murill ss. Heinem, a basidiomycete native from Brazil, frequently used by popular medicine, mainly in the form of tea, was assessed to its antiviral action against herpes simplex type 1 (HSV-1) and bovine herpes type 1 (BoHV-1) in HEp-2 cell culture. Viral replication inhibition was evaluated by plaque assay and immunofluorescence test. The extract demonstrated virucide action for both viruses, being more effective against HSV-1, inhibiting its infectivity in 78.4 and 73.9% at the concentrations of 50 and 100 µg/mL, respectively moreover, reduction in 47% the number of fluorescent cells was observed for both concentrations. The extract also showed discrete therapeutic activity. These results suggest that A. blazei extract acts mainly in the viral particle, however, the effect during virus replication can not be ruled out.
O extrato aquoso de Agaricus blazei Murill ss. Heinem, um basidiomiceto nativo do Brasil, usado na medicina popular, na forma de chá, foi avaliado quanto suas propriedades antivirais contra herpes simplex tipo 1 (HSV-1) e herpes bovino tipo 1 (BoHV-1) em cultura de células HEp-2. A inibição da replicação viral foi monitorada pelos ensaio de placa e reação de imunofluorescência. O extrato apresentou atividade virucida mais efetiva do que terapêutica para ambos os vírus, sendo mais efetivo portanto para HSV-1, inibindo em mais de 70% o número de plaques e em cerca de 47% o número de células apresentando fluorescência específica, nas concentrações de 50 e 100 µg/mL, nas duas técnicas utilizadas. Os resultados obtidos sugerem que o extrato aquoso de A. blazei deve agir principalmente sobre a partícula viral, embora a inibição durante o ciclo replicativo do vírus não deva ser excluída.
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bruggemann2006brazilianantiviral Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Rafaela Bruggemann;Janaina Matsuo Orlandi;Fabricio Jose Benati;Ligia Carla Faccin;Mario Sergio Mantovani;Carlos Nozawa;Rosa Elisa Carvalho Linhares
Journal ieee software
Year 2006
DOI
10.1590/S1517-83822006000400029
URL
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822006000400029
Keywords
hsv-1

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