synthesis, crystal structure, stacking effect and antibacterial studies of a novel quaternary copper (ii) complex with quinolone

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2003
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Abstract
The structural properties of a new copper (II) complex [Cu2(cip)2(bpy)2(pip)]·6H2O (bpy=2,2’-bipyridyl, cip=1-cyclopropyl-6-4-oxo-1,4-dihydroquinoline-3-carboxylic acid, pip= piperazinyl anion), obtained during the synthesis of the copper complex with ciprofloxacin (cpf), has been investigated. The complex crystallizes in the triclinic system, space group P-1. The cell dimensions are: a=6.874(2) Å, b= 10.761(3) Å, c= 17.969(5) Å, α =80.071(6)°, β= 85.253(6)°, γ=79.109(6)°，V=1284.5(6) Å3, and Z=2. The Cu (II) ion displays a five-coordinate square pyramidal coordination with two nitrogen donors from bpy, the 4-keto and 3-carboxylate oxygen donors of cip, and the third nitrogen atom of the pip anion occupying the fifth site. There is a stack effect between cip ring and bpy ring from another molecule, where the stacking distance is about 3.5 Å. The results of elemental analysis and FT-IR measurement are also included. Both ligand and complex were assayed against gram-positive and gram-negative bacteria by the doubling dilutions method. The complex shows the same minimal inhibitory concentration (MIC) against S. Aureus and E. Coli bacteria as the corresponding ligand.
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zhu2003moleculessynthesis, Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Longguan Zhu;Xuchun Fu;Guoping Wang;Guangguo Wu
Journal Journal of ethnopharmacology
Year 2003
DOI
10.3390/80200287
URL
http://www.mdpi.com/1420-3049/8/2/287/
Keywords
synthesis crystal structure Ciprofloxacin antibacterial activity copper complex quinolone ft-ir spectroscopyorganic chemistry

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