proteome analysis of bronchoalveolar lavage fluid in lung fibrosis associated with systemic sclerosis

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ID: 235982
2010
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Abstract
Background: Interstitial lung disease (ILD) is the major cause of mortality in collagen vascular diseases. However, its pathogenesis still needs to be elucidated. Methods: To evaluate the alteration of certain proteins in bronchoalveolar lavage fluid (BALF) and clarify the causative role in the processes of ILD in systemic sclerosis (SSc), we compared a BALF protein profile between 5 patients with systemic sclerosis with pulmonary fibrosis (SSc-fib+) and 4 patients with systemic sclerosis without pulmonary fibrosis (SSc-fib-) using two-dimensional gel electrophoresis (2-DE), and matrix assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF MS). Results: We analyzed spots over the range of 10.1 kDa to 207.4 kDa. SSc-fib+ patients showed increased 3 proteins compared to SSc-fib- including α2-macroglobulin, α1-antitrypsin, and pulmonary surfactant protein A and decreased 2 proteins including α2 heat shock protein (HSP) and glutathione S-transferase (GST) compared to SSc-fib- patients. Conclusions: In conclusion, we identified several interesting proteins that might have roles in ILD of SSc patients. Further studies are warranted to clarify the role of these proteins in the processes of pulmonary fibrosis in SSc.
Reference Key
shirahama2010allergologyproteome Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Ryutaro Shirahama;Yasunari Miyazaki;Tsukasa Okamoto;Naohiko Inase;Yasuyuki Yoshizawa
Journal current drug discovery technologies
Year 2010
DOI
10.2332/allergolint.10-OA-0176
URL
http://www.sciencedirect.com/science/article/pii/S1323893015306535
Keywords
inflammation pulmonary fibrosis scleroderma bronchoalveolar lavage allergy

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