thyrotoxic periodic paralysis: clinical challenges

Clicks: 123
ID: 234737
2014
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Abstract
Thyrotoxic periodic paralysis (TPP), a disorder most commonly seen in Asian men, is characterized by abrupt onset of hypokalemia and paralysis. The condition primarily affects the lower extremities and is secondary to thyrotoxicosis. The underlying hyperthyroidism is often subtle causing difficulty in early diagnosis. Factors like high-carbohydrate meal exercise, steroid, and stress can precipitate an attack of TPP. Evidence is building up showing role of genetic mutations in Kir2.6 channel in the pathogenesis of TPP. Loss of function of Kir2.6 together with increased activity of Na+/K+ ATPase may trigger a positive feed-forward cycle of hypokalemia. Biochemical hyperthyroidism with normal urinary potassium excretion and ECG changes are characteristic of TPP. Treatment with low-dose potassium supplements and nonselective beta-blockers should be initiated upon diagnosis, and the serum potassium level should be frequently monitored to prevent rebound hyperkalemia.
Reference Key
vijayakumar2014journalthyrotoxic Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Abhishek Vijayakumar;Giridhar Ashwath;Durganna Thimmappa
Journal geotechnical testing journal
Year 2014
DOI
10.1155/2014/649502
URL
http://dx.doi.org/10.1155/2014/649502
Keywords
clinical endocrinology diseases of the endocrine glands

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