control of brown adipose tissue glucose and lipid metabolism by pparγ

Clicks: 327
ID: 234520
2011
Free PDF
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Popular

Ranked #46 of 262 articles by views in aip advances

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 262 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Brown adipose tissue (BAT) non-shivering thermogenesis impacts energy homeostasis in rodents and humans. Mitochondrial UCP1 in brown fat cells produce heat by dissipating the energy generated by the oxidation of fatty acids and glucose. In addition to thermogenesis and despite its small relative size, sympathetically activated BAT constitutes an important glucose, fatty acid and triacylglycerol-clearing organ, and such function could potentially be used to alleviate dyslipidemias, hyperglycemia and insulin resistance. To date, chronic sympathetic innervation and PPARγ activation are the only recognized inducers of BAT recruitment. Here, we review the major differences between these two inducers of BAT recruitment in the regulation of lipolysis, fatty acid oxidation, lipid uptake and triacylglycerol synthesis, glucose uptake and de novo lipogenesis. Whereas BAT recruitment through sympathetic drive translates into functional thermogenic activity, PPARγ-mediated recruitment is associated with a reduction in sympathetic activity leading to increased lipid storage in brown adipocytes. The promising therapeutic role of brown adipose tissue in the treatment of hypertriglyceridemic and hyperglycaemic conditions are also discussed.
Reference Key
festuccia2011frontierscontrol Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;William T. Festuccia;Pierre-Gilles eBlanchard;Yves eDeshaies
Journal aip advances
Year 2011
DOI
10.3389/fendo.2011.00084
URL
http://journal.frontiersin.org/Journal/10.3389/fendo.2011.00084/full
Keywords
obesity lipid metabolism sympathetic nervous system brown adipose tissue pparγ clinical endocrinology

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.