polyurethane/polylactide-blend films doped with zinc ions for the growth and expansion of human olfactory ensheathing cells (oecs) and adipose-derived mesenchymal stromal stem cells (ascs) for regenerative medicine applications
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2016
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Abstract
Polymeric biomaterials based on polyurethane and polylactide blends are promising candidates for regenerative medicine applications as biocompatible, bioresorbable carriers. In current research we showed that 80/20 polyurethane/polylactide blends (PU/PLDL) with confirmed biological properties in vitro may be further improved by the addition of ZnO nanoparticles for the delivery of bioactive zinc oxide for cells. The PU/PLDL blends were doped with different concentrations of ZnO (0.001%, 0.01%, 0.05%) and undertaken for in vitro biological evaluation using human adipose stromal stem cells (ASCs) and olfactory ensheathing cells (OECs). The addition of 0.001% of ZnO to the biomaterials positively influenced the morphology, proliferation, and phenotype of cells cultured on the scaffolds. Moreover, the analysis of oxidative stress markers revealed that 0.001% of ZnO added to the material decreased the stress level in both cell lines. In addition, the levels of neural-specific genes were upregulated in OECs when cultured on sample 0.001 ZnO, while the apoptosis-related genes were downregulated in OECs and ASCs in the same group. Therefore, we showed that PU/PLDL blends doped with 0.001% of ZnO exert beneficial influence on ASCs and OECs in vitro and they may be considered for future applications in the field of regenerative medicine.
| Reference Key |
marycz2016polymerspolyurethane/polylactide-blend
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| Authors | ;Krzysztof Marycz;Monika Marędziak;Jakub Grzesiak;Dariusz Szarek;Anna Lis;Jadwiga Laska |
| Journal | Journal of Fluorescence |
| Year | 2016 |
| DOI |
10.3390/polym8050175
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| URL | |
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