effect of topical administration of fractions and isolated molecules from plant extracts on skin wound healing: a systematic review of murine experimental models

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ID: 234051
2016
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Abstract
Background and Purpose. Skin wound healing is a dynamic process driven by molecular events responsible for the morphofunctional repair of the injured tissue. In a systematic review, we analyzed the relevance of plant fractions and isolates on skin wound healing. By revising preclinical investigations with murine models, we investigated if the current evidence could support clinical trials. Methods. Studies were selected in the MEDLINE/PubMed and Scopus databases according to the PRISMA statement. All 32 identified studies were submitted to data extraction and the methodological bias was investigated according to ARRIVE strategy. Results. The studies demonstrated that plant fractions and isolates are able to modulate the inflammatory process during skin wound healing, being also effective in attenuating the oxidative tissue damage in the scar tissue and stimulating cell proliferation, neoangiogenesis, collagen synthesis, granulation tissue expansion, reepithelialization, and the wound closure rate. However, we identified serious methodological flaws in all studies, such as the high level of reporting bias and absence of standardized experimental designs, analytical methods, and outcome measures. Conclusion. Considering these limitations, the current evidence generated from flawed methodological animal studies makes it difficult to determine the relevance of herbal medicines to treat skin wounds and derails conducting clinical studies.
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sarandy2016mediatorseffect Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Mariáurea Matias Sarandy;Fernanda Barbosa Lopes;Sérgio Luis Pinto da Matta;Marcus Vinicius Mello Pinto;Sirlene Souza Rodrigues Sartori;Rômulo Dias Novaes;Reggiani Vilela Golçalves
Journal polyhedron
Year 2016
DOI
10.1155/2016/4916068
URL
http://dx.doi.org/10.1155/2016/4916068
Keywords
pathology

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