cd200/cd200r paired potent inhibitory molecules regulating immune and inflammatory responses; part i: cd200/cd200r structure, activation, and function
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ID: 234029
2012
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Abstract
CD200/CD200R are highly conserved type I paired membrane glycoproteins that belong to the Ig superfamily containing a two immunoglobulin‑like domain (V, C). CD200 is broadly distributed in a variety of cell types, whereas CD200R is primarily expressed in myeloid and lymphoid cells. They fulfill multiple functions in regulating inflammation. The interaction between CD200/CD200R results in activation of the intracellular inhibitory pathway with RasGAP recruitment and thus contributes to effector cell inhibition. It was confirmed that the CD200R activation stimulates the differentiation of T cells to the Treg subset, upregulates indoleamine 2,3‑dioxygenase activity, modulates cytokine environment from a Th1 to a Th2 pattern, and facilitates an antiinflammatory IL‑10 and TGF‑β synthesis. CD200/CD200R are required for maintaining self‑tolerance. Many studies have demonstrated the importance of CD200 in controlling autoimmunity, inflammation, the development and spread of cancer, hypersensitivity, and spontaneous fetal loss.
| Reference Key |
holmannov2012actacd200/cd200r
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|---|---|
| Authors | ;Drahomíra Holmannová;Martina Koláčková;Kateřina Kondělková;Pavel Kuneš;Jan Krejsek;Ctirad Andrýs |
| Journal | journal of the brazilian chemical society |
| Year | 2012 |
| DOI |
10.14712/18059694.2015.68
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| URL | |
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