astragalus extract mixture ht042 increases longitudinal bone growth rate by upregulating circulatory igf-1 in rats
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2017
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Abstract
Astragalus extract mixture HT042 is a standardized ingredient of health functional food approved by Korean FDA with a claim of “height growth of children.” HT042 stimulates bone growth rate and increases local IGF-1 expression in growth plate of rats which can be considered as direct stimulation of GH and its paracrine/autocrine actions. However, it remains unclear whether HT042 stimulates circulatory IGF-1 which also plays a major role to stimulate bone growth. To determine the effects on circulatory IGF-1, IGF-1 and IGFBP-3 expressions and phosphorylation of JAK2/STAT5 were evaluated in the liver after 10 days of HT042 administration. HT042 upregulated liver IGF-1 and IGFBP-3 mRNA expression, IGF-1 protein expression, and phosphorylation of JAK2/STAT5. HT042 also increased bone growth rate and proliferative zonal height in growth plate. In conclusion, HT042 stimulates bone growth rate via increment of proliferative rate by upregulation of liver IGF-1 and IGFBP-3 mRNA followed by IGF-1 protein expression through phosphorylation of JAK2/STAT5, which can be regarded as normal functioning of GH-dependent endocrine pathway.
| Reference Key |
lee2017evidence-basedastragalus
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|---|---|
| Authors | ;Donghun Lee;Sung Hyun Lee;Yoon Hee Lee;Jungbin Song;Hocheol Kim |
| Journal | ACS applied materials & interfaces |
| Year | 2017 |
| DOI |
10.1155/2017/6935802
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| URL | |
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