interactions between neutrophils and pseudomonas aeruginosa in cystic fibrosis

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ID: 234013
2017
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Abstract
Cystic fibrosis (CF) affects 70,000 patients worldwide. Morbidity and mortality in CF is largely caused by lung complications due to the triad of impaired mucociliary clearance, microbial infections and chronic inflammation. Cystic fibrosis airway inflammation is mediated by robust infiltration of polymorphonuclear neutrophil granulocytes (PMNs, neutrophils). Neutrophils are not capable of clearing lung infections and contribute to tissue damage by releasing their dangerous cargo. Pseudomonas aeruginosa is an opportunistic pathogen causing infections in immunocompromised individuals. P. aeruginosa is a main respiratory pathogen in CF infecting most patients. Although PMNs are key to attack and clear P. aeruginosa in immunocompetent individuals, PMNs fail to do so in CF. Understanding why neutrophils cannot clear P. aeruginosa in CF is essential to design novel therapies. This review provides an overview of the antimicrobial mechanisms by which PMNs attack and eliminate P. aeruginosa. It also summarizes current advances in our understanding of why PMNs are incapable of clearing P. aeruginosa and how this bacterium adapts to and resists PMN-mediated killing in the airways of CF patients chronically infected with P. aeruginosa.
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rada2017pathogensinteractions Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Balázs Rada
Journal computational and mathematical methods in medicine
Year 2017
DOI
10.3390/pathogens6010010
URL
http://www.mdpi.com/2076-0817/6/1/10
Keywords
biofilm Pseudomonas aeruginosa cystic fibrosis phagocytosis oxidative neutrophil extracellular traps neutrophil killingmedicine

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