triglycerides/glucose and triglyceride/high-density lipoprotein cholesterol indices in normal and preeclamptic pregnancies: a longitudinal study
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2018
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Abstract
Metabolic changes have been correlated with adverse pregnancy outcomes. The aim of the present study is to determine the TyG and TG/HDL-c indices in a cohort of healthy pregnant (n=142), preeclamptic (n=18), and healthy nonpregnant women (n=56). Preeclamptic women were selected from the same cohort. Pregnant women were followed during three periods of pregnancy and postpartum. The results showed a significant increase in the values of TyG and TG/HDL-c (p<0.01) as pregnancy progresses, without significant differences between healthy and preeclamptic women. TyG and TG/HDL-c indices are significantly low in nonpregnant and three months’ postpartum women when compared with each gestational period studied. TyG and TG/HDL-c indices are positively correlated with HOMA-IR in the early and middle pregnancy (p<0.05). Multiple linear regression using the TyG and TG/HDL-c indices as dependent variables showed that TyG index was significantly associated with HOMA-IR, gestational age, HDL-c, TC, LDL, fasting insulin, and mean BP (p<0.001); meanwhile, TG/HDL-c index was only associated with HOMA-IR (p<0.0242) and gestational age (p<0.001). In conclusion, the TyG and TG/HDL-c indices could be useful in monitoring insulin resistance during pregnancy.
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| Reference Key |
poveda2018internationaltriglycerides/glucose
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|---|---|
| Authors | ;Natalia Elvira Poveda;María Fernanda Garcés;Aquiles Enrique Darghan;Silvia Alejandra Blanco Jaimes;Estefania Pulido Sánchez;Luz Amparo Díaz-Cruz;Carmen Doris Garzón-Olivares;Mario Orlando Parra-Pineda;Alejandro Antonio Bautista-Charry;Edith Ángel Müller;Héctor Fabio Sandoval Alzate;Luis Miguel Maldonado Acosta;Elizabeth Sanchez;Ariel Iván Ruíz-Parra;Jorge Eduardo Caminos |
| Journal | zhonghua wei zhong bing ji jiu yi xue |
| Year | 2018 |
| DOI |
10.1155/2018/8956404
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| URL | |
| Keywords |
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