effect of immunotherapy on basophil activation induced by allergens in patients with atopic dermatitis
Clicks: 307
ID: 233818
2014
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This
article has not been analysed, so there is no overall score —
reader engagement is measured and shown alongside.
Reader Engagement
Steady Performance
30.0
/100
307 views
45 readers
AI Quality Assessment
Not analyzed
Readership in this journal
SteadyRanked #11 of 28 articles by views in journal of nepal medical association
Most read
Least read
Bar heights use a square-root scale.
Mint this article as an NFT
Not yet mintedCreate a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.
5
SUSD
one-off · no wallet required
Abstract
Background: Subcutaneous allergen-specific immunotherapy (IT) is a proved, highly effective treatment for respiratory IgE-mediated diseases. However, few studies have explored the immunological mechanisms of IT in patients with atopic dermatitis.
Objective: To explore the immune response of atopic dermatitis patients receiving house dust mite (HDM) immunotherapy, according to humoral response and basophil activation.
Material and method: An open label study was done which assessed the severity of atopic dermatitis with SCORAD in 20 patients (10 with immunotherapy and 10 without it) every three months during two years. Serum samples were taken before the follow up, and at the rst and second year of study to analyze CD63 basophil expression, total IgE levels and speci c IgE and IgG4 to Der p and Der f. Ten patients with allergic rhinitis receiving IT and 5 non-allergic subjects were used as controls.
Results: CD63 expression after basophil stimulation with Der p was higher in atopic dermatitis patients than in rhinitis and non-allergic subjects. After the rst and second year of treatment, CD63 expression was lower in atopic dermatitis active group than in the atopic dermatitis control group. We observed a correlation between SCORAD, IgG4 and CD63 expression.
Conclusion: In patients with atopic dermatitis, basophil activation test could be a biomarker of clinical response and basophil modulation can result in a better clinical control.
| Reference Key |
snchez2014revistaeffect
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | ;Jorge Sánchez;Ricardo Cardona |
| Journal | journal of nepal medical association |
| Year | 2014 |
| DOI |
10.29262/ram.v61i3.42
|
| URL | |
| Keywords |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.