mammalian gut immunity

Clicks: 123
ID: 233765
2014
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Abstract
The mammalian intestinal tract is the largest immune organ in the body and comprises cells from non-hemopoietic (epithelia, Paneth cells, goblet cells) and hemopoietic (macrophages, dendritic cells, T-cells) origin, and is also a dwelling for trillions of microbes collectively known as the microbiota. The homeostasis of this large microbial biomass is prerequisite to maintain host health by maximizing beneficial symbiotic relationships and minimizing the risks of living in such close proximity. Both microbiota and host immune system communicate with each other to mutually maintain homeostasis in what could be called a "love-hate relationship." Further, the host innate and adaptive immune arms of the immune system cooperate and compensate each other to maintain the equilibrium of a highly complex gut ecosystem in a stable and stringent fashion. Any imbalance due to innate or adaptive immune deficiency or aberrant immune response may lead to dysbiosis and low-grade to robust gut inflammation, finally resulting in metabolic diseases.
Reference Key
chassaing2014biomedicalmammalian Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Benoit Chassaing;Manish Kumar;Mark T Baker;Vishal Singh;Matam Vijay-Kumar
Journal osteoarthritis and cartilage
Year 2014
DOI
10.4103/2319-4170.130922
URL
http://www.biomedj.org/article.asp?issn=2319-4170;year=2014;volume=37;issue=5;spage=246;epage=258;aulast=Chassaing
Keywords
innate immunity microbiota toll-like receptorsmedicine (general)biology (general)

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