biochanin a modulates cell viability, invasion, and growth promoting signaling pathways in her-2-positive breast cancer cells

Clicks: 166
ID: 233683
2009
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Abstract
Overexpression of HER-2 receptor is associated with poor prognosis and aggressive forms of breast cancer. Scientific literature indicates a preventive role of isoflavones in cancer. Since activation of HER-2 receptor initiates growth-promoting events in cancer cells, we studied the effect of biochanin A (an isoflavone) on associated signaling events like receptor activation, downstream signaling, and invasive pathways. HER-2-positive SK-BR-3 breast cancer cells, MCF-10A normal breast epithelial cells, and NIH-3T3 normal fibroblast cells were treated with biochanin A (2–100 μM) for 72 hours. Subsequently cell viability assay, western blotting and zymography were carried out. The data indicate that biochanin A inhibits cell viability, signaling pathways, and invasive enzyme expression and activity in SK-BR-3 cancer cells. Biochanin A did not inhibit MCF-10A and NIH-3T3 cell viability. Therefore, biochanin A could be a unique natural anticancer agent which can selectively target cancer cells and inhibit multiple signaling pathways in HER-2-positive breast cancer cells.
Reference Key
sehdev2009journalbiochanin Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Vikas Sehdev;James C. K. Lai;Alok Bhushan
Journal joule
Year 2009
DOI
10.1155/2009/121458
URL
http://dx.doi.org/10.1155/2009/121458
Keywords
neoplasms Oncology including cancer and carcinogens tumors

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