follicular lymphoma: a clinicopathological analysis from a tertiary care institute in southern india

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ID: 233457
2016
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Abstract
Introduction Follicular lymphoma (FL) is an indolent chronic lymphoproliferative disorder of B-cells with variable clinical behaviour. It is the second most common subtype of Non-Hodgkin lymphoma in western countries but reported to have a lower incidence in Asia. Materials and methods Cases of FL diagnosed in the Department of Pathology of our Institute from January 2009 to June 2015 were included in the study. The clinicopathological parameters including staging, histological details and immunohistochemical markers CD20, CD10, Bcl2 and Ki67 were recorded in all the cases. Results Of the 497 cases of Non-Hodgkin Lymphoma reported during the study period, 36 (7.2%) cases were follicular lymphoma. The mean age was 50 years with male to female ratio of 3.2:1. Grade 1/ 2 was seen in 70% cases. 22 % cases had low grade with high proliferation index (Ki67 > 40%). Granulomatous response was seen in two cases. Diffuse large cell lymphoma component was present in four cases. Bone marrow involvement and peripheral blood spill was seen in 12 (37.5%) and six cases (18.8%) respectively. 72% cases were in stage 3 or 4. Conclusion Incidence of FL was lower in our study than other Indian studies. FL presented in the elderly, with male predominance and disseminated stage. Features of low grade with high proliferation index, granulomatous response, leukemic involvement and transformation to high grade lymphoma are highlighted in the study.
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Authors ;Mary Theresa Sylvia;Biswajit Dey;Debdatta Basu;Sajini Elizabeth Jacob;Rakhee Kar;Biswajit Dubashi
Journal aktualʹnì pitannâ farmacevtičnoï ì medičnoï nauki ta praktiki
Year 2016
DOI
10.4084/mjhid.2016.060
URL
http://www.mjhid.org/index.php/mjhid/article/view/2719
Keywords
follicular lymphoma granuloma grade high-proliferation-indexdiseases of the blood and blood-forming organs

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